Analysis name: ADvsControl
Enrichment database: Reactome_2016
| Control (N=20) |
AD (N=24) |
Overall (N=44) |
|
|---|---|---|---|
| PHF1 | |||
| Mean (SD) | 0.0985 (0.236) | 1.67 (1.12) | 1.20 (1.19) |
| Median [Min, Max] | 0.00623 [0.000519, 0.679] | 1.92 [0.00839, 3.57] | 0.679 [0.000519, 3.57] |
| Missing | 12 (60.0%) | 5 (20.8%) | 17 (38.6%) |
| amyloid | |||
| Mean (SD) | 0.422 (0.333) | 3.61 (2.68) | 2.70 (2.69) |
| Median [Min, Max] | 0.334 [0.0456, 0.968] | 3.13 [0.0577, 8.38] | 1.48 [0.0456, 8.38] |
| Missing | 12 (60.0%) | 4 (16.7%) | 16 (36.4%) |
| PMD | |||
| Mean (SD) | 26.2 (12.2) | 25.1 (14.0) | 25.6 (13.1) |
| Median [Min, Max] | 23.0 [9.00, 47.0] | 23.5 [8.00, 53.0] | 23.0 [8.00, 53.0] |
Dependent variable: diagnosis Differential
expression design: ~diagnosis + age + sex + PMD
Log2 Fold Change threshold: 0.2
Adjusted p value threshold: 0.05
Filter protein coding genes: TRUE
Dependent variable: diagnosis
Differential expression design: ~0 + diagnosis
Actual design (if denoising in processing step): ~0 +
diagnosis + PMD + sex + age
Log2 Fold Change threshold: 0.2
Adjusted p value threshold: 0.05
Correlation between transcriptomics/proteomics: 0.2318711
We found a r=0.2318711 correlation between pairwise log2FoldChanges (p-value <0.05) indicating a moderate positive correlation between the mRNA and protein level changes, which is reinforced by the existence of discordant pairs.
## No pathways were found to be significantly up regulated
multiGSEA works with nested lists where each sublist represents an omics layer. The function rankFeatures calculates the pre-ranked features, that are needed for the subsequent calculation of the enrichment score. rankFeatures calculates the a local statistic ls based on the direction of the fold change and the magnitude of its significance
Omix v1.0.0 – 2023-06-30 16:04:44
A report by Omix