Performs DE on the multimodal object from the processed slots — DE_multiomics • Omix

Performs DE on the multimodal object from the processed slots

DE_multiomics(
  multiassay,
  dependent = "diagnosis",
  covariates = c("pmi", "msex", "age_death"),
  levels = c("Control", "Mid", "Late"),
  log2FoldChange = 0.2
)

Arguments

multiassay: Multiassay experiment object generated by Omix generate_multiassayfunction
dependent: Dependent variable for the differential expression analysis, usually the disease group variable
covariates: Technical and biological covariates. Set as NULL is data is denoised.
levels: Character vector with reference group as first element.
log2FoldChange: Log2FC absolute threshold. Default to 0.2

Value

List of differential expression results

See also

Other Single-omic: protein_DE_analysis(), rna_DE_analysis(), single_omic_comparisons(), spls_wrapper(), wgcna_wrapper()